Transformative Concepts for Drug Design: Target Wrapping

By Ariel Fernández

Book Overview

Protein Cooperativity and Wrapping: Two Themes in the Transformative Platform of Molecular Targeted Therapy.- Wrapping Defects and the Architecture of Soluble Proteins.- Folding Cooperativity and the Wrapping of Intermediate States of Soluble Natural Proteins.- Wrapping Deficiencies and De-wetting Patterns in Soluble Proteins: A Blueprint for Drug Design.- Under-Wrapped Proteins in the Order-Disorder Twilight: Unraveling the Molecular Etiology of Aberrant Aggregation.- Evolution of Protein Wrapping and Implications for the Drug Designer.- Wrapping as a Selectivity Filter for Molecular Targeted Therapy: Preliminary Evidence.- Re-engineering an Anticancer Drug to Make It Safer: Modifying Imatinib to Curb Its Side Effects.- Wrapping Patterns as Universal Markers for Specificity in the Therapeutic Interference with Signaling Pathways.- Fulfilling a Therapeutic Imperative in Cancer Treatment: Control of Multi-target Drug Impact.- Inducing Folding By Crating the Target.- Wrapper Drugs as Therapeutic Editors of Side Effects.- Wrapper Drugs for Personalized Medicine.- Last Frontier and Back to the Drawing Board: Protein-Water Interfacial Tension in Drug Design.

• Format: Paperback
• Language: English
• ISBN: 3642424589
• ISBN13: 9783642424588
• Release Date: December 2014
• Publisher: Springer
• Length: 230 Pages
• Weight: 0.76 lbs.
• Dimensions: 0.5" x 6.1" x 9.2"