Reforming science education/reforming physiology education.- What is the new paradigm and what is new about it?- What are the core concepts of physiology?- What does it mean to "unpack" a core concept?- The "unpacked" core concept of homeostasis.- The "unpacked" core concept of flow down gradients.- The "unpacked" core concept of cell-cell communication.- Organizing an introductory physiology course based on core.- Teaching physiology using the new paradigm: three examples.- Using core concepts in physiology in designing learning resources.- Conceptual assessment of student learning.- Core concepts and the physiology curriculum.- Extending the paradigm.- Summing up.