Receptors in the Evolution and Development of the Brain: Matter Into Mind

By Richard E Fine and Richard E. Fine MD

Receptors in the Evolution and Development of the Brain: Matter Into Mind addresses the key role of receptors and their cognate ligands from an evolutionary developmental biology perspective. This book emphasizes the importance of receptors in wiring the brain correctly along with rapid eye movement (REM) sleep, and apoptosis as mechanisms to destroy miswired neurons. There is a great focus on receptor functions in the evolution of the nervous system and development of the large vertebrate brain. Additional topics include the role of receptors in alcohol and drug damage to the brain, viral destruction of neurons, connectional diseases including Alzheimer's and Parkinson's, and the potential of neuronal stem cell treatments for these diseases. This book is extremely useful to graduate students with an interest in the molecular, cellular, cognitive, and clinical neurosciences, and to all readers curious about the ability of the human brain to build its incredibly complex self. Key Features, Provides an understanding of the key role receptors play in brain development and the selection process necessary to construct a large brain, Traces the evolution of receptors from the most primitive organisms to humans, Emphasizes the roles that REM sleep and apoptosis play in wiring the brain correctly via trophic factors and receptors, Discusses an important corollary to the key role of receptors in correct wiring and the quantization of receptors and their cognate ligands, possibly leading to an increased understanding of synaptic pruning during neurodevelopment, Also addresses the role of receptors in damage to the developing brain by addictive drugs (including alcohol and tobacco), and in neuronal destruction by viruses, such as polio and Zika, Describes the role that trophic factor-receptor interactions play throughout life and how trophic deficits can lead to "connectional" diseases including Alzheimer's, Parkinson's, Huntington's, ALS, and prion diseases such as bovine spongiform encephalopathy (Mad Cow Disease), Provides a potential mechanism whereby neuronal stem cells can cure these diseases Book jacket.

• Format: Paperback
• Language: English
• ISBN: 0128110120
• ISBN13: 9780128110126
• Release Date: June 2019
• Publisher: Academic Press
• Length: 282 Pages
• Weight: 1.35 lbs.
• Dimensions: 0.6" x 7.5" x 9.1"