Platinum-Based Drugs in Cancer Therapy

By Nicholas P. Farrell and Lloyd R. Kelland

Book Overview

Leading international experts comprehensively review all aspects of platinum anticancer drugs and their current use in treatment, as well as examining their future therapeutic prospects. Writing from a variety of disciplines, these authorities discuss the chemistry of cisplatin in aqueous solution, the molecular interaction of platinum drugs with DNA, and such exciting new areas as DNA mismatch repair and replicative bypass, apoptosis, and the transport of platinum drugs into tumor cells. The emergent platinum drugs of the future-orally active agents, the sterically hindered ZD0473, and the polynuclear charged platinum BBR3464-are also fully considered. Timely and interdisciplinary, Platinum-Based Drugs in Cancer Therapy offers cancer therapeutics specialists an illuminating survey of every aspect of platinum drugs from mechanisms of action to toxicology, tumor resistance, and new analogs.

• Format: Paperback
• Language: English
• ISBN: 1617370916
• ISBN13: 9781617370915
• Release Date: December 2010
• Publisher: Humana
• Length: 341 Pages
• Weight: 1.10 lbs.
• Dimensions: 0.7" x 6.1" x 9.2"

Customer Reviews

Excellent book for chemists

This book is aimed at specialists interested in the chemistry and biology of platinum based cancer chemotherapeutic drugs. Unfortunately the level of specific scientific knowledge (required at the university level at the least) to understand key concepts in the book, is very high and is therefore not recommended for readers who are just interested in learning about cancer or chemotherapy.For those who do have a tertiary background in science, particularly in chemistry, they will find that this book one of the best publications ever. Written by two experts in the field Professor Nicholas Farrell (Virginia Commonwaelth University) and Professor Lloyd Kelland (Institute of Cancer Reserach England), the book covers all areas of platinum chemistry from synthesis and DNA binding to cytotoxicity and cellular uptake.As a single publication this book is an excellent review of all major work that has occurred since the discovery of cisplatin in the late 1960's.This book is a definite must for scientists entering, or already conducting research into platinum chemotherapy.