Nitrofurantoin To treat simple UTIs, doctors use nitrofurantoin, an antibiotic. It is very efficient against both gram-positive and gram-negative bacteria. According to a number of authoritative recommendations, nitrofurantoin is the drug of choice for treating simple UTIs in the lower urinary tract. Nitrofurantoin's popularity has risen again because of the rise in the number of bacteria that are resistant to modern antibiotics and produce an enzyme called extended-spectrum beta-lactamase (ESBL). This exercise will help healthcare practitioners effectively lead patient treatment when nitrofurantoin is indicated by outlining its indications, mechanism of action, routes of administration, major side effects, contraindications, monitoring, and toxicity.
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