Jak-Stat Signaling: From Basics to Disease

By Thomas Decker and Mathias Müller

Book Overview

The continuing fascination with Jaks and Stats: An introduction .- Regulation of JAKs: Insights gleaned from the functional protein domains .- Nuclear functions of the Janus Kinases .- Self-association of STAT proteins from monomers to paracrystals .- How Stats interact with the molecular machinery of transcriptional activation .- Nongenomic Functions of STAT3 .-Evolution of Jak and Stat proteins .- JAK/STAT and chromatin regulation in Drosophila . JAK/STAT signaling and invertebrate immune responses .- Stat5 as a hematopoietic master regulator for differentiation and neoplasia development .- Regulation of dendritic cell development by STATs .- STAT transcription factors - Controlling all aspects of NK cell biology .- Function of JAKs and STATs in lymphocytes: Bench to bedside .- The role of Janus kinases in hematopoietic malignancies .- Activation of Janus kinases during tumorigenesis . STAT1 and STAT3 transcription factors in inflammation-associated colon cancer .- Universal and specific functions of STAT3 in solid tumours .- Impact of STAT5 on normal tissue development and cancer .- Crosstalk with the Jak-STAT pathway in inflammation .- Activation and inhibition of JAK-STAT signal transduction by RNA viruses .- Multifaceted antiviral actions of interferon-stimulated gene products .- Interferon regulation of the innate response to bacteriaEvolution of Jak and Stat proteins .- JAK/STAT and chromatin regulation in Drosophila . JAK/STAT signaling and invertebrate immune responses .- Stat5 as a hematopoietic master regulator for differentiation and neoplasia development .- Regulation of dendritic cell development by STATs .- STAT transcription factors - Controlling all aspects of NK cell biology .- Function of JAKs and STATs in lymphocytes: Bench to bedside .- The role of Janus kinases in hematopoietic malignancies .- Activation of Janus kinases during tumorigenesis . STAT1 and STAT3 transcription factors in inflammation-associated colon cancer .- Universal and specific functions of STAT3 in solid tumours .- Impact of STAT5 on normal tissue development and cancer .- Crosstalk with the Jak-STAT pathway in inflammation .- Activation and inhibition of JAK-STAT signal transduction by RNA viruses .- Multifaceted antiviral actions of interferon-stimulated gene products .- Interferon regulation of the innate response to bacteria.

• Format: Paperback
• Language: English
• ISBN: 3709117526
• ISBN13: 9783709117521
• Release Date: July 2014
• Publisher: Springer
• Length: 450 Pages
• Weight: 1.42 lbs.
• Dimensions: 0.9" x 6.1" x 9.2"