Issues in Risk Assessment

By National Research Council, Commission on Life Sciences, Division on Earth and Life Studies

The scientific basis, inference assumptions, regulatory uses, and research needs in risk assessment are considered in this two-part volume. The first part, Use of Maximum Tolerated Dose in Animal Bioassays for Carcinogenicity, focuses on whether the maximum tolerated dose should continue to be used in carcinogenesis bioassays. The committee considers several options for modifying current bioassay procedures. The second part, Two-Stage Models of Carcinogenesis, stems from efforts to identify improved means of cancer risk assessment that have resulted in the development of a mathematical dose-response model based on a paradigm for the biologic phenomena thought to be associated with carcinogenesis.

• Format: Paperback
• Language: English
• ISBN: 0309047862
• ISBN13: 9780309047869
• Release Date: February 1993
• Publisher: National Academies Press
• Length: 374 Pages
• Weight: 1.00 lbs.
• Dimensions: 1.0" x 6.0" x 9.0"