Drug Metabolism and Transport: Molecular Methods and Mechanisms

By Lawrence H. Lash

Book Overview

A compendium of proven experimental approaches and strategies for studying the bioactivation, detoxification, tissue distribution, and elimination of xenobiotics in the metabolism and/or transport of various chemicals. The authors address several of the major drug metabolizing systems, including the cytochrome P450 family, flavin-containing monooxygenases, glutathione, S-transferase, glucuronidation, N-acetylation, and sulfotransferases. Additional chapters present novel approaches to the study of: signaling pathways in the regulation of drug metabolism enzymes, how the modulation of thiols and other low molecular-weight cofactors can alter drug metabolism, and how modulation of drug metabolism pathways can influence antiviral therapy.

• Format: Paperback
• Language: English
• ISBN: 1617374946
• ISBN13: 9781617374944
• Release Date: November 2010
• Publisher: Humana
• Length: 388 Pages
• Weight: 1.29 lbs.
• Dimensions: 0.9" x 6.0" x 9.0"